Melatonin analogue new indole hydrazide/hydrazone derivatives with antioxidant behavior: Synthesis and structureactivity relationships

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dc.contributor.authorSüzen, Sibel
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.contributor.otherGürkök, Gökce
dc.contributor.otherÇoban, Tülay
dc.date.accessioned2020-03-18T07:37:22Z
dc.date.available2020-03-18T07:37:22Z
dc.date.issued2009
dc.description.abstractMelatonin (MLT) is a hormone produced in the brain by the pineal gland, from the amino acid tryptophan. It is also an antioxidant hormone with a particular role in the protection of nuclear and mitochondrial DNA. In recent years, many physiological properties of MLT have been described resulting in much attention in the development of synthetic compounds possessing the indole ring. Sixteen MLT analogue indole hydrazide/hydrazone derivatives were synthesized and in vitro antioxidant activity was investigated. Most of the compounds showed significantly higher activity than MLT at 10- 3 M and 10- 4 M concentrations.tr_TR
dc.description.indexwos
dc.identifier.endpage515tr_TR
dc.identifier.issue2tr_TR
dc.identifier.startpage506tr_TR
dc.identifier.urihttps://doi.org/10.1080/14756360802218516tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70721
dc.identifier.volume24tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1080/14756360802218516tr_TR
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistrytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectAntioxidant activitytr_TR
dc.subjectHydrazidetr_TR
dc.subjectHydrazoneIndoletr_TR
dc.subjectMelatonintr_TR
dc.subjectSynthesistr_TR
dc.titleMelatonin analogue new indole hydrazide/hydrazone derivatives with antioxidant behavior: Synthesis and structureactivity relationshipstr_TR
dc.typeArticletr_TR

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